Principal AI/ML Platform Engineer

Required:

12+ years in software/data/ML engineering, with 8+ years in AI/ML engineering at scale.

Expertise in building production-grade ML/LLM systems on AWS tech stack (E.g. Python, LangChain/Llamaindex, CrewAI, Vector databases, Agent runtimes, TensorFlow/PyTorch, Spark, MLflow).

Proven track record with GenAI/LLMs: fine-tuning, RAG, prompt orchestration, safety guardrails, monitoring, and cost optimization.

Deep knowledge of AI/ML intensive systems, distributed architectures, and cloud-native development.

Familiarity with AI governance frameworks, LLM safety, drift detection, bias detection, hallucination, explainability, and compliance (e.g., HIPAA, CLIA, FDA).

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit

www.natera.com

.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

All qualified applicants are encouraged to apply, and will be considered without regard to race, color, religion, gender, gender identity or expression, sexual orientation, national origin, genetics, age, veteran status, disability or any other legally protected status. We also consider qualified applicants regardless of criminal histories, consistent with applicable laws.

The Principal AI/ML Platform Engineer is responsible for build and delivery of the next generation of Natera’s Generative AI and ML platforms. This is a hands-on technical leadership role at the intersection of engineering excellence, platform design, and applied GenAI/ML innovation. This role requires deep expertise in AI engineering at scale, with a passion for building robust, compliant, and high-performance systems that directly impact patient outcomes and clinical innovation.

You will design, build, and scale enterprise-grade Gen AI and ML platforms and services that power internal workflows (R&D, Lab Ops, Clinical Trials, Billing, Patient/Provider engagement) and external-facing AI/ML products. As the most senior leader in the AI/ML engineering team, you will also set technical standards, mentor engineers, and drive adoption of cutting-edge techniques such as retrieval-augmented generation (RAG), advanced prompt engineering, vector search, GenAI governance, evaluation frameworks, ML/LLMOps, model experimentation, observability, and compliance-first AI pipelines. You will be responsible for development of a production-ready AI platform with reusable components used to deploy multiple AI solutions across Natera’s business units in a federated approach. You will also develop clear standards and best practices established for AI/ML development across the organization.