Director, Small Molecule Discovery Biology (Inflammation & Autoimmunity)

Prior experience with function-level oversight of project biology and/or biochemistry efforts, or overall project team leadership

Knowledge of and hands on experience with emerging areas of small molecule drug discovery, such as protein-protein interaction inhibitors, degraders and molecular glues, and transcription factors

Expertise spanning from early-stage target discovery and validation through early clinical development

Awareness of methods for compound screening, characterizing mechanism of action, transcriptomics, and proteomics

Familiarity with autoimmune disease biology including in vitro and in vivo immunology models, immortalized cell lines, isolation and characterization of primary immune cells, RNA-Seq, and cytokine detection methodologies

Prior management of CRO collaborations, with an existing familiarity of a wide variety of biology CROs

Health insurance premiums paid at 90% for employee, 80% for dependents

Free access to Genentech Bus & Ferry Share program

$100 monthly cell phone stipend

Unlimited PTO for Exempt employees

Free onsite gym and a kitchen stocked with yummy snacks and drinks!

We are a hard-working, collaborative team on a mission to transform patient’s lives-- and we aspire to

Taking biology department responsibility in discovery-stage small molecule projects including conceptualizing project strategy, recognizing knowledge gaps, formulating screening paradigms, overseeing SAR generation, coordinating among project stakeholders, and identifying potential new targets

Overseeing development of both biochemical and cellular read-outs to support small molecule drug discovery efforts Support characterization of small molecule clinical candidates by employing autoimmune disease models and developing clinically relevant PD assays

Providing both direct and indirect supervision of laboratory-based biology staff

Manage external biology studies performed at CROs.

Collaborating effectively with cross-functional teams including medicinal chemistry, DMPK, and preclinical development.