Quantitative Virology-Immunology - Postdoctoral Researcher

Background in mechanistic virology, viral entry, receptor biology, host-pathogen interactions, viral immune evasion, viral tropism, humoral immunology, B cell receptor repertoire studies, or vaccine design.

Experience with pseudotyped virus systems, neutralization/entry assays, or related infectious-disease models.

Experience with membrane proteins, endosomal trafficking, cell-surface receptor biology, conformationally dynamic proteins, or complex glycoproteins.

Experience with high-throughput protein production, mutational panels, display-based screening, surfaceome or interactomics datasets, crosslinking/MS, or other protein-protein interaction assays.

Experience with structural biology data, integrative structural modeling, cryo-EM, X-ray crystallography, SAXS, HDX-MS, crosslinking MS, or structure-guided assay design.

Programming or scripting skills for data analysis, visualization, automation, or workflow development.

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Position Information

This is a Postdoctoral appointment with the possibility of extension to a maximum of three years, open to those who have been awarded a PhD at time of hire date.

Why Lawrence Livermore National Laboratory?

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Postdoctoral Researcher in quantitative virology and immunology to contribute to interdisciplinary projects at the intersection of mechanistic virology, host-pathogen interactions, structural modeling, and rational vaccine design.

The successful candidate will help drive experimental biology for projects that connect computational protein interface predictions and partner-generated interaction maps to functional biological outcomes.

Current applications include mapping and validating virus-host receptor interfaces, evaluating engineered protein variants, characterizing viral antigen and immune recognition interfaces, and supporting immunogen-design efforts aimed at steering protective immune responses.

The work supports LLNL missions in biosecurity, threat preparedness, and biodefense.

This position is in the Microbiology/Immunology Group in the Biosciences and Biotechnology Division within the Physical and Life Sciences Directorate

Conduct mentored research in quantitative virology, immunology, and host-pathogen biology, with emphasis on protein-protein interactions relevant to viral entry, immune recognition, and vaccine design.

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Lawrence Livermore National Laboratory (LLNL) has turned bold ideas into world-changing impact advancing science and technology to strengthen U.S. security and promote global stability.

Our mission spans four critical national security areas nuclear deterrence, threat preparedness, energy security, and multi-domain defense empowering teams to take on the toughest challenges of today and tomorrow. With a culture built on innovation and operational excellence, LLNL is a place where your expertise can make a real impact.