Principal Scientist, Antibody Discovery and Engineering

Demonstrated track record independently leading therapeutic antibody discovery campaigns from concept through lead identification, optimization, or nomination.

Deep technical expertise in antibody biology, antibody structure and function, discovery platforms, and therapeutic antibody optimization.

Hands-on experience with immunization-based antibody discovery, including antigen design, immunization strategy, B cell screening, single-cell sorting, B cell culturing, antibody sequence recovery, and NGS-informed repertoire analysis.

Strong expertise in display technologies for antibody engineering, affinity maturation, specificity optimization, developability improvement, and molecular-format optimization.

Strong molecular biology and antibody engineering skills, including cloning, library construction, sequence analysis, expression construct design, antibody expression, purification, and analytical characterization.

Expertise in antibody characterization assays and platforms, including affinity determination, epitope binning, competition assays, specificity profiling, developability assessment, Biacore, Carterra, Octet, ELISA, MSD, multi-parameter flow cytometry, or related technologies.

At Moderna, we believe that when you feel your best, you can do your best work.

That’s why our benefits and well-being resources are designed to support you—at work, at home, and everywhere in between.

Competitive healthcare, plus voluntary benefit programs to support your unique needs

A holistic approach to well-being, with access to fitness, mindfulness, and mental health support

Family planning benefits, including fertility, adoption, and surrogacy support

Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown

Moderna is seeking an accomplished and highly motivated Principal Scientist to join the Antibody Discovery team within Therapeutics Research.

Therapeutics Research generates innovative therapeutic concepts and advances them from early scientific idea through First-in-Human studies.

The Antibody Discovery team plays a central role in discovering, engineering, and optimizing antibody-based therapeutic molecules that enable new treatment strategies across Moderna's therapeutic pipeline.

This Principal Scientist will lead integrated antibody discovery and engineering campaigns across oncology and autoimmune disease programs.

The role spans concept development through lead identification, including biological and therapeutic-area research, target and antigen strategy, immunization and B cell discovery campaign design, antibody screening, sequence analysis, engineering, characterization, and optimization.

The successful candidate will bring deep expertise in therapeutic antibody discovery, antibody engineering, immune repertoire mining, display technologies, and molecular-format optimization.

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit

modernatx.com/careers

to learn more about our current opportunities.