Sr. Scientist, Therapeutics & Translational Bioinformatics

Strong scientific foundation in both computational biology and immunology, with the ability to connect molecular and cellular findings to immune mechanisms, human disease biology, and therapeutic development.

Demonstrated experience applying computational analyses to human, preclinical and in vitro datasets to support therapeutic development, early drug discovery, and translational decision-making.

Relevant experience in immune-mediated diseases, oncology, infectious diseases, immunotherapy, or the development of mRNA therapeutics or vaccines.

Strong expertise in processing, analyzing, and biologically interpreting bulk and single-cell transcriptome and integration with multiple omics modalities.

Strong experience analyzing single-cell TCR or BCR repertoire data, including integration of V(D)J information with cellular phenotypes and transcriptomic states.

Demonstrated experience developing or applying machine-learning methods and advanced statistical models, such as mixed-effects and Bayesian approaches, to biological, immunological, or clinical datasets.

At Moderna, we believe that when you feel your best, you can do your best work.

That’s why our benefits and well-being resources are designed to support you—at work, at home, and everywhere in between.

Competitive healthcare, plus voluntary benefit programs to support your unique needs

A holistic approach to well-being, with access to fitness, mindfulness, and mental health support

Family planning benefits, including fertility, adoption, and surrogacy support

Generous paid time off, including vacation, volunteer days, sabbatical, global recharge days, and a discretionary year-end shutdown

Moderna is seeking a highly motivated and experienced Senior Scientist, Therapeutics & Translational Bioinformatics, to join a multidisciplinary team supporting the discovery and development of mRNA-based therapeutics and vaccines.

The role will advance early therapeutic development through computational analysis of human, clinical, and preclinical data while deepening our understanding of mRNA platform immunology through translational studies.

This person will apply expertise in computational biology, immunology, machine learning/AI, and advanced statistical methods to identify therapeutic targets, biological mechanisms, biomarkers, response signatures, and patient-level factors that inform program strategy.

The successful candidate will have strong hands-on experience with bulk and single-cell transcriptomics and TCR/BCR repertoire analysis, integrated multi-omics, and machine-learning or deep-learning approaches.

The person will lead the computational effort for therapeutic or platform programs, partnering with multidisciplinary teams, and external collaborators to define scientific questions, guide study design, lead analyses, and translate biological data into actionable next steps.

Lead the computational effort for therapeutic and translational programs, partnering with Research, Translational Medicine, and Clinical Development teams to define computational strategies, data requirements, and analysis plans from discovery through early clinical development.

Since our founding in 2010, we have aspired to build the leading mRNA technology platform, the infrastructure to reimagine how medicines are created and delivered, and a world-class team. We believe in giving our people a platform to change medicine and an opportunity to change the world.

By living our mission, values, and mindsets every day, our people are the driving force behind our scientific progress and our culture. Together, we are creating a culture of belonging and building an organization that cares deeply for our patients, our employees, the environment, and our communities.

We are proud to have been recognized as a Science Magazine Top Biopharma Employer, a Fast Company Best Workplace for Innovators, and a Great Place to Work in the U.S.

If you want to make a difference and join a team that is changing the future of medicine, we invite you to visit

modernatx.com/careers

to learn more about our current opportunities.