Principal Software Engineer

Work on the platform that powers Natera's R&D — a small, high-leverage team where individual contribution is highly visible.

Operate at the frontier of AI-augmented software engineering. We don't just talk about AI tooling — we build it, and use it daily.

Significant autonomy and influence over the team's technical direction.

Competitive salary and benefits.

We value diversity and are committed to creating an inclusive environment for all employees. We encourage applicants of all backgrounds to apply.

Compensation & Total Rewards

We're seeking a Principal Software Engineer to join Natera's R&D Platform Infrastructure team.

The team builds the cloud infrastructure, workflow platforms, and data platforms that R&D uses to do its science — including a Kubernetes-based workflow execution platform, a custom R&D LIMS system, and a set of supporting tools that routinely handle production-scale workloads.

This is a senior technical role.

You'll own the full architecture, implementation, and delivery of large projects across our platform.

You'll partner with the team lead on roadmap and tough technical calls, mentor mid-level engineers, and help the team find the right solution for the problem — not the most elaborate one.

We're a small team (4 engineers + lead) with broad scope, and we're heavily AI-augmented: every engineer uses Claude Code / Cursor as a daily tool, and we build our own AI tooling (custom plugins, MCP servers, agents) to multiply ourselves.