Principal Scientist, Process Chemistry

Assessment and application of new trends and concerns in process development, quality and manufacturing to Praxis’ products.

Manage quarterly budgeting of drug substance relevant activities.

Minimum of 5+ years of industry experience in CMC specifically for small molecule drug substance.

A scientific track record or working knowledge in continuous processing, catalysis, biocatalysis and/or high throughput experimentation desirable.

Strong knowledge of CMC development across all phases of drug development from initial regulatory filings through registration, validation and launch.

Experience in working with third-party CRO / CMO partners and associated service providers to develop and manufacturing pharmaceutical products.

At Praxis, we believe that taking care of our people (and

their

people) is important, so we provide a world class benefits package to help you thrive.  This includes 99% of the premium paid for medical, dental and vision plans.  We also provide company-paid life insurance, AD&D, disability benefits, and voluntary plans to personalize your coverage. Thinking about the future?  We match dollar-for-dollar up to 6% on eligible 401(k) contributions and sweeten the deal with long-term stock incentives and ESPP.  We provide a discretionary quarterly bonus, an extremely flexible wellness benefit, generous PTO, paid holidays and company-wide shutdowns.  Not to mention, you'll also be joining a phenomenal crew of colleagues who are smart, engaged and inspiring.  We aim high, collaborate hard, and produce results.  Let’s achieve the impossible together!

To round out our world-class total rewards package, we provide annualized base salary compensation in the range listed below.  Final salary range may be modified commensurate with job level, education, and experience.

Annualized Base Salary

$165,000

We’re seeking a Principal Scientist in Process Chemistry to lead drug substance activities for one or more projects within Praxis’ portfolio to support clinical and commercial supply.  Apply your knowledge to design products & processes to support clinical phase testing and then mature them through development to commercial supply.

You are a key leader in the development of drug substance processes for our small molecule products.  You’ll also work closely within the CMC and project teams under Agile management to identify requirements and constraints of our product in order to define a work plan that will lead to the successful manufacturing and creation of a data package to support commercial regulatory submissions.

Leads the Process Chemistry Research and Development for one or more projects from early to late phase within Praxis.

Designs both early phase and late-phase/commercial drug substance process and then leads their demonstration from lab to pilot plant.

Provides chemistry and technical leadership throughout the lifecycle

Participates/leads activities to identify final API forms for pharmaceutical development.

Praxis Precision Medicines is a clinical-stage biopharmaceutical company translating genetic insights into the development of therapies for central nervous system disorders characterized by neuronal imbalance.  At Praxis we share a common vision of reshaping the human condition into a more freeing and fulfilled existence by developing high impact medicines for patients and families affected by and living with complex brain disorders.  Our core Values of

Trust

,

Ownership

,

Curiosity