Senior Scientist I, Analytical Development

Minimum Qualifications:

Bachelor’s degree in Chemistry, Biology, Biochemistry, or related discipline with 7+ years of applicable experience, or Master’s degree with 5+ years, or Ph.D. with 0–3 years of experience in a related field.

Hands-on experience with relevant analytical techniques (i.e. HPLC-MS, GC-FID, etc) and equipment.

Preferred Qualifications:

Advanced technical understanding of oligonucleotide manufacturing processes.

Working knowledge of chromatography and/or other software including ChemDraw, JMP, Empower, MassLynx, Chromeleon, and/or Waters Connect.

The typical pay range for this exempt role is:

Minimum: $ 93,750 /Salary

Maximum: $ 156,250 /Salary

This range represents the low and high end of the anticipated salary range for the California -based position.  The actual base salary will depend on several factors such as: experience, skills, and location.

What we offer (US based-employees):

Competitive compensation with strong bonus program

The Senior Scientist I, Analytical Development at LGC AxoLabs will serve as a subject matter expert (SME) in analytical method development and validation for oligonucleotide drug substances within a Contract Manufacturing Organization (CMO) environment. This role involves leading analytical initiatives, providing technical guidance to cross-functional teams, and engaging with clients to ensure the accurate characterization and in-process testing of oligonucleotide API and raw materials in compliance with regulatory standards.

LGC AxoLabs has an extensive, ever-evolving global client base and impressive technical capabilities within a state-of-the-art GMP facility. As the organization continues to grow, we seek technically adept and highly motivated candidates who can contribute to innovative solutions in oligonucleotide analytical development. The successful candidate will be detail-oriented, proficient in advanced analytical chemistry techniques, and experienced in oligonucleotide analysis. This role requires strong problem-solving skills, technical leadership, and direct interaction with clients to support their project needs.

Routine tasks include leading analytical HPLC method development, validation, and other analytical studies (e.g. forced degradation, MS/MS sequencing, stability) for custom oligonucleotide APIs and raw materials. The Senior Scientist I is responsible for managing multiple development projects, leading technical discussions, and facilitating fulfilment of project deliverables according to established timelines.

To perform this job successfully, an individual must be able to perform each essential function satisfactorily.

Essential Functions:

Serve as a subject matter expert (SME) in analytical HPLC method development and validation for oligonucleotide APIs and raw materials.

LGC Axolabs is a business unit of LGC, and a leading provider of CRO / CDMO capability to the therapeutic oligonucleotide discovery and development industry. Centered out of LGC’s site in Kulmbach, Germany, Axolabs works closely with its customers to assist the identification and development of lead candidates with a broad suite of bioinformatics, biology, chemistry, manufacturing and analytical services that support discovery, pre-clinical and clinical trials and scale-up manufacture. With a track record in Nucleic Acid Therapeutics that traces back more than 20 years, Axolabs provides deep knowledge and expertise in the services it provides, working collaboratively and responsively with its clients to assist them in achieving their objectives.

LGC Axolabs facility in Petaluma is focused on manufacturing scale-up and cGMP production of multigram to kilograms of API for pre-clinical and clinical development. Our California site has been experience in oligonucleotide synthesis over three decades and established the therapeutic manufacturing capability in 2018. With around 70 staff and two GMP manufacturing trains, Axolabs offers a flexible manufacturing service out of Petaluma that draws where necessary on our industry and chemical and analytical expertise in Kulmbach.