Medicinal Drug Design Lead, London

Essential:

PhD in Medicinal Chemistry, Synthetic Organic Chemistry, or a related technical field, or equivalent industrial experience.

5+ years’ professional experience in a Medicinal Chemistry role, operating within a biotech, pharma or CRO setting.

Proven track record of leading medicinal chemistry efforts on drug discovery projects, demonstrating significant contributions to project progression (ideally from hit identification through to lead optimisation/candidate nomination), with familiarity of optimisation of DMPK.

Experience of contributing to structure-based drug design problems.

Excellent strategic thinking, problem-solving, and decision-making capabilities applied to complex drug discovery challenges.

As part of the ongoing expansion of our Drug Design and Medical Research function, we are hiring Medicinal Drug Design Leads. You will work as a Chemistry Lead, delivering scientific expertise and strategic direction to fulfil milestone objectives on our portfolio projects. You will support the business alongside world leading AI/ML Drug Design Platform teams, and will work collaboratively to drive improvements in the platform and apply these to impactful drug design projects. Please note that this is a scientific leadership role, where you will take an active hands-on role as an individual contributor rather than being a people manager, although you will support and mentor junior colleagues.

If you are a skilled Medicinal Chemist with a passion for applying cutting-edge technology to complex scientific challenges, this role offers an unparalleled opportunity for impact and growth.

Invent new medicines. Rapidly drive drug discovery programs to value inflection points by deploying your knowledge of modern discovery principles and synthetic organic chemistry, taking ownership as a Medicinal Chemistry Lead.

Collaborate cross-functionally to support the data-driven delivery of high quality scientific solutions to complex technical problems.

Represent the company externally, interacting with existing and prospective collaborators and Contract Research Organisations (CROs).

We are a dynamic team of Medicinal Chemists transforming how drugs are designed. By partnering deeply with our AI/ML colleagues, we are doing more than just leveraging the Isomorphic Labs drug design engine - we are actively shaping it. We use our domain expertise to challenge and refine our algorithms, creating a powerful symbiotic relationship that drives our internal and collaborative portfolios. Our team work closely together in a supportive environment, where everyone is valued for their medicinal chemistry expertise and experience they bring to the group. We have a strong growth mindset and prioritise continued development and learning.