manifoldbio
Scientist, cDNA Display
At a Glance
- Location
- Boston
- Posted
- 2026-03-04T13:50:22-05:00
Key Requirements
Domain Knowledge
- Automation
- Engineering
Requirements
Hands-on experience with cell-free selection systems (cDNA display, mRNA display, ribosome display, or similar)
Strong molecular biology fundamentals and demonstrated ability to develop and troubleshoot complex, multi-step workflows
Experience with or strong interest in laboratory automation
Track record of successfully automating complex laboratory workflows
Background in therapeutic antibody discovery or protein engineering
Experience with computational protein design
Responsibilities
Design, develop, and validate a cell-free display platform (cDNA display or similar) compatible with diverse binder formats
Work with automation team to scale and automate the platform to enable routine, high-throughput screening against large panels of therapeutic targets
Collaborate with ML and computational teams to ensure screening outputs feed effectively into model training pipelines
Work with the protein engineering team to support discovery campaigns and affinity maturation as platform capacity allows
Stay current on advances in cell-free display, laboratory automation, and computational protein design