manifoldbio

Scientist, cDNA Display

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At a Glance

Location
Boston
Posted
2026-03-04T13:50:22-05:00

Key Requirements

Domain Knowledge

  • Automation
  • Engineering

Requirements

Hands-on experience with cell-free selection systems (cDNA display, mRNA display, ribosome display, or similar)

Strong molecular biology fundamentals and demonstrated ability to develop and troubleshoot complex, multi-step workflows

Experience with or strong interest in laboratory automation

Track record of successfully automating complex laboratory workflows

Background in therapeutic antibody discovery or protein engineering

Experience with computational protein design

Responsibilities

Design, develop, and validate a cell-free display platform (cDNA display or similar) compatible with diverse binder formats

Work with automation team to scale and automate the platform to enable routine, high-throughput screening against large panels of therapeutic targets

Collaborate with ML and computational teams to ensure screening outputs feed effectively into model training pipelines

Work with the protein engineering team to support discovery campaigns and affinity maturation as platform capacity allows

Stay current on advances in cell-free display, laboratory automation, and computational protein design