vaxcyte
Associate Scientist I (Contract), Research
At a Glance
- Location
- San Carlos, California, United States
- Experience
- 6+ years
- Posted
- 2026-07-23T11:12:20-04:00
Key Requirements
Domain Knowledge
- Automation
Requirements
Experience with diverse protein targets, bacterial and eukaryotic recombinant proteins, small/large subunit vaccine antigens, fusion proteins, multimeric complexes, glycoproteins, and VLPs.
Familiarity capture/polishing methods and orthogonal cleaning strategies appropriate for potential vaccine antigens.
Familiarity with automation or high throughput workflows such as (96-well plates) and UNICORN/AKTA software DoE integrations.
Responsibilities
Execute the following AKTA FPLC chromatography techniques:
Immobilized metal affinity chromatography (IMAC)
Ion-exchange chromatography (IEX)
Hydrophobic interaction chromatography (HIC)
Size-exclusion chromatography (SEC)
Designing chromatography trains to reduce host cell protein, endotoxin and aggregates using complementary modalities.